Sarcoidosis is No Mystery – The Symptoms and Signs of the Disease

Sarcoidosis is defined as a systemic granulomatous inflammatory disease that is characterized by non-caseating granulomas (small inflammatory nodules). The cause of this disease is unknown. The small inflammatory nodules appear most often in the lungs or in the lymph nodes. However, virtually any organ of the body can be affected. The onset of this disease is gradual. It may be asymptomatic or chronic. This can also lead to death.

The Sarcoidosis Is No Mystery is systemic disease and can affect any organ. The common symptoms of this disease is vague. They are fatigue unchanged by sleep, lack of energy, weight loss, aches and pains, arthritis, dry eyes, swelling of the knees, blurry vision, shortness of breath, a dry hacking cough or skin lesions. It is sometimes difficult to distinguish sarcoidosis from cancer because they may mimic one another. The symptoms that are cutaneous vary they will range from rashes and noduli (small bumps) to erythema nodosum or lupus perino. These are often asymptomatic. If renal, liver, heart, or brain is involved this may cause further symptoms and altered functioning. When sarcoidosis affects the brain or nerve it is called neurosarcoidosis.

About 30 to 70 percent of patients with sarcoidosis do not require therapy. The standard treatment is prednisolone, which has been used for many years. This treatment can slow or reverse the disease in some patients while other patients will not respond to the prednisolene therapy. It has been a controversial topic to use prednisolene for a mild case of the disease because the disease will remit spontaneously. The prednisolene is known to have many dose and duration side effects. The use of these is usually limited to severe, progressive, or organ-threatening disease. The influence that corticosteroids has on the natural history is unclear.

A person with severe Sarcoidosis Is No Mystery symptoms are usually treated with azathioprine and methotrexate. In rare cases, cyclophosphamide is used. The granulomas are caused by collections of immune system cells, particularly T cells, and because of this there has been some early indications of success using immunosuppressants, interleukin 2 inhibitors or anti-tumor necrosis factor alpha treatment(such as infliximab). Unfortunately, none of these have proven to be a reliable treatment. With these have been significant side effects such as an increased risk of reactivating latent tuberculosis. A followup on a person with sarcoidosis is important because the disease affects multiple organ systems.