Sarcoidosis and vitamin D exhibit a tight connection. Especially the active hormone of vitamin D (1,25-dihydroxyvitamin-D or 1,25-D). This hormone is what causes monocytes (a particular type of white blood cells important for immune responses) and the basic white blood cell (leukocyte) to grow into the giant cells that are a common characteristic of sarcoidosis. The relationship between vitamin D and sarcoidosis was first recognized by Harrell and Fisher in 1939.
The connection between sarcoidosis and this part of vitamin D is very direct and it actually means that without 1,25-D there would be no granuloma formation.
Yes, this sounds bad, but 1,25-D is the same hormone is the same hormone that is responsible for the proper functioning of proper operation of the Parathyroid gland, Pancreas, Bone, Intestine, Kidneys, Heart and the Brain.
Sarcoidosis and vitamin D – hypercalciuria or hypercalcemia
Vitamin D was the primary suspect for the hypercalciuria or hypercalcemia in sarcoidosis (excess calcium levels in urine and blood) for a very long time, but recent studies deny this. It was proven that the levels of calcium in the urine are primarily regulated by the Parathyroid Hormone (PTH). Today, the official standpoint is that vitamin D takes part in these processes but is not primarily responsible for hypercalciuria or hypercalcemia in sarcoidosis.
Sarcoidosis and vitamin D – possible consequences of increased levels
It is essential to keep the levels of vitamin D and 1,25-D under control. Normal levels for 1,25-D are those bellow 45pg/ml and this point is called the Merck maximum. High levels of vitamin D and its active hormone can lead to changes in muscles function, especially the cardiac muscle.
Sarcoidosis and vitamin D – osteoclasts activation
Even at levels that of 42 pg/ml of 1,25-D there are significant problems in the body of a sarcoidosis patient. This level of hormone is proven to stimulate osteoclasts (a type of bone cell that removes bone tissue by removing its mineralized matrix) which lead to bones being resorbed back to the bloodstream. This then leads to osteoporosis (disease of bone that leads to an increased risk of fracture) as well as deposits of calcium in the soft tissue of the body (lungs, breasts, kidneys).
Sarcoidosis and vitamin D – Exciting news
Sarcoidosis and vitamin D connection may have been revealed but sarcoidosis remains a mysterious disease, primarily when it comes to the underlying causes. But some recent development offer hope to the sarcoid patients. A new holistic approach that is addressing the chemical imbalances that have been overseen in the past is returning some astounding result. It is known as the Aden Protocol.