Premenstrual syndrome effects over 70% to 90% of women before menopause in the US and less for women in Southeast Asia because of their difference in living style and social structure. It is defined as faulty function of the ovaries related to the women’s menstrual cycle, it effects a women’s physical and emotional state, and sometimes interferes with daily activities as a result of hormone fluctuation. The syndrome occurs one to two weeks before menstruation and then declines when the period starts. In this article, we will discuss how progesterone therapy effects women with PMS.
I. How conventional treatment – Progesterone therapy effects women with PMS
Since progesterone is produced after ovulation and PMS occurs in the second half of the menstrual cycle, some researchers believe that deficiency of progesterone or hormone imbalance between estrogen and progesterone may be the caused for pre-menstrual syndrome. Since progesterone is easily broken down if it taken by mouth, it normally is given by form of cream or vagina pessaries which is a device which supports the vagina and needed to be changed every 3 to six months.
II. Side effects
1. Weight change and water retention
Using the progesterone hormone therapy may increase the risk of potassium deficiency because high levels of progesterone in the bloodstream during menstrual cycle inhibits potassium leading to abnormal lymphatic and kidney function in water and fluid regulation resulting in water retention and weigh change.
Using progesterone hormone replacement therapy highly increases the progesterone levels in bloodstream during the luteal stage of the menstrual cycle resulting in outbreak of acne.
3. Breast tenderness
Progesterone therapy increases the levels of progesterone that inhibits the levels of magnesium leading to magnesium deficiency and imbalance the levels of prostaglandins production resulting in breast tenderness.
4. Other PMS
Progesterone hormone replacement therapy may help to relieve some symptoms of PMS but it causes other PMS symptoms such as irritability, anxiety and depression.
5. Irregular menstrual cycle
Some women treated with progesterone therapy may experience a various abnormal symptoms such as excessive bleeding, no cycle for months at a time, very painful periods or ovulation.