Through different authoritative studies, it is becoming clear that lack of beneficial niacin side effect is considered as a risk factor in various cardiovascular diseases. Although it has long been established that atherosclerosis, for example, is the result of periodic accumulation of cholesterol-induced plaque deposits in the arterial blood vessels, only a few are completely aware that niacin actually advances the same heart condition. Majority of mainstay treatments for high cholesterol focuses on the direct reduction of LDL cholesterol in the bloodstream without initially preventing excess cholesterol production.
Cardiovascular diseases, such as atherosclerosis, are fatal in effect. Individuals with atherosclerosis are permanently at the risk of acute or complete stoppage in critical blood flow to key organs, such as the heart and brain. When it does occur, cellular and tissue death occurs within few minutes after having been dismantled with essential oxygen supply. Death of the person occurs within an hour, mostly with minimal signs long before its sunset.
One problem with primary medical treatment is that it is typically reactive. It treats diseases after they have been acquired. It is seldom preventive and proactive.
Atherosclerosis briefly discussed
Atherosclerosis occurs after LDL cholesterol molecules are oxidized by free radicals, especially oxygen free radicals. This largely explains why chronic inflammation of the blood vessels takes place in the arms because the latter are rich in fresh oxygen supplies. Atherosclerosis rarely develops in the veins where there is minimal oxygen dissolved in the outgoing blood flow.
Cholesterol is not dissolved in the blood, the latter being made up of 70% water. When oxidized LDL cholesterol settles down on the inner arterial walls, various defensive reactions occur. The body's autoimmune system perceives them as potential disease risk factors, triggering the release of macrophage white blood cells.
Being essentially a fatty and complex substance, cholesterol is seldom absorbed by the macrophage white blood cells. They continue to accumulate until the arterial linings are ruptured. This event leads to inflammation and formation of blood clots.
If not appreciated immediately, atheromatous plaques accumulate inside the arteries. When at least 50% of the entire arterial lumen area is used up by those deposits, blood flow is significantly constricted, resulting to diminished supply of fresh oxygen and nutrients to the regular functioning of key organs, such as the heart and brain. Myocardial infarction or heart attack takes place when fresh blood supply stops going to the heart's muscles.
Heart disease is a leading cause of death in the US today
Heart disease is the leading cause of mortality in the United States and Canada in 2007. According to the American Heart Association, one American dies from coronary diseases every 34 seconds. In myocardial infarction, death of the person normally occurs within an hour if it is not treated as a medical emergency.
When taken regularly over prolonged period, niacin is responsible in blocking the breakdown of fats in adipose tissues. It specifically leads to the conversion of fats into very low-density lipoprotein (VLDL). VLDL is the main cause of the production of low-density lipoprotein (LDL), commonly called as "bad" cholesterol.
VLDL and bad cholesterol is normally produced by the liver. Due to the beneficial niacin side effect in breaking down fats causing free fatty acids, the liver is inhibited in secreting more of the VLDL and LDL cholesterol. This has been reported in a 2006 book entitled "Basic and Clinical Pharmacology" written by Bertram Katzung, a well-respected authority in his field.
Find out how niacin lowers bad cholesterol level
PL Canner and colleagues conducted a study in 1986, investigating cases of myocardial infarction of 8,341 men, aging 30 to 64 years. The niacin group has shown 11% reduction in mortality rate compared with those treated with placebo. Niacin increases high-density lipoprotein (HDL) or "good" cholesterol. This led to doctors prescribing niacin supplements to patients at risk of heart attack.
Niacin belongs to a group of B vitamins. It is also called as Vitamin B3 or nicotinic acid, which is a water-soluble nutrient essential in normal body performance.
Optimal beneficial effects are obtained when niacin is combined with chromium, another essential element linked to heart disease. A study conducted at the John Hopkins University has shown that reduced amount of chromium in the body increases significantly the risk of heart attacks. Xtend-Life of New Zealand, well known in producing proactive and natural supplements, came up with Cardio-Klenz supplement that contains powerful 29 bio available compounds, chromium nicotinate being one of them.
Check out the company website for more thorough niacin side effect, among others, protecting your heart and the entire circulatory system.