Various Nexium side effects are known to occur. Below is a look at some side effects which have been categorized by body system.
Gastrointestinal – Gastrointestinal side effects that may occur as a result of taking nexium include bowel irregularity, dyspepsia, aggravated constipation, dysplasia, epigastric pain, dysphagia, eructation, anorexia, esophageal disorder, frequent stools, gastroenteritis, GI hemorrhage, rectal disorder, increased appetite, ulcerative stomatitis, vomiting as well as certain reported cases of pancreatitis.
Nervous System – Nervous system adverse effects occurring as a result of taking nexium include: dizziness, confusion, insomnia, hypoesthesia, migraine aggravation, paresthesia, sleep disorder, tremor, somnolence and vertigo.
Cardiovascular – Cardiovascular adverse effects reported as resulting from Nexium include hypertension, chest pain, angioedema, tachycardia and substernal chest pain.
Musculoskeletal – Musculoskeletal adverse effects as a result of taking Nexium include arthralgia, cramps, aggravation of arthritis, arthropathy, hernia, fibromyalgia syndrome, polymyalgia rheumatica, hypertonia, back pain, as well as some reported incidences of myalgia and hip fracture. Studies have shown an increased risk of hip fracture from taking Nexium – which risk was significantly high among patients who had been prescribed long-term high PPIs.
Hematologic – Hematologic adverse effects that occur from taking Nexium include anemia, hypochromic anemia, epistaxis, cervical lymphadenopathy, leukopenia, leukocytosis, thrombocytopenia, as well as certain reported cases of agranulocytosis and pancytopenia.
Hepatic – Hepatic side effects as a result of using Nexium include bilirubinemia, abnormal hepatic function, an increase in SGOT and SGPT, as well as reported cases of hepatitis, with or without jaundice.
Metabolic – Metabolic adverse effects that occur as a result of using Nexium include excessive thirst, glycosuria, hyponatremia, hyperuricemia, increased alkaline phosphatase, vitamin B12 deficiency, as well as weight increase/decrease.
Genitourinary – Genitourinary adverse effects resulting from using Nexium include cystitis, impotence, abnormal urine, hematuria, albuminuria, dysuria, micturition frequency, moniliasis, genital moniliasis, vaginitis, dysmenorrhea, menstrual disorder and polyuria.
Psychiatric – Psychiatric side effects from using Nexium are confusion, apathy, aggravated depression and nervousness, as well as a rare reported case of loss of libido. In this case loss of normal sexual function leading to complete unresponsiveness was reported in a patient taking Nexium.
Respiratory – Respiratory side effects that have been reported as a result of using Nexium include coughing, aggravated asthma, pharyngitis, dyspnea, larynx edema, rhinitis and sinusitis.
General – General side effects that occur as a result of taking Nexium are fatigue, hot flushes, malaise, flu-like disorder, leg edema, pain, earache, fever, tinnitus, otitis, parosmia, loss and perversion of taste and enlarged abdomen.
Ocular – Ocular side effects reported as a result of taking Nexium are conjunctivitis, abnormal vision, and visual field defect, along with cases of blurred vision.
Dermatologic – Dermatologi adverse effects occurring as a result of taking Nexium include skin inflammation, acne, pruritus, dermatitis, erythematous rash, maculopapular rash, increased sweating, as well as reported cases of alopecia and erythema multiforme. There have also been further reported cases of esophagitis, duodenitis, gastric ulcer, esophageal stricture, hernia, esophageal ulceration, esophageal varices, gastritis, benign polyps or nodules, Barrett’s esophagus and mucosal discoloration.
Hypersensitivity – Less than 1% of hypersensitivity side effects as a result of taking Nexium have included allergic reactions.