Gabapentin (Neurontin) is given by mouth with food or between meals. If Gabapentin dose is lessened, interrupted or replaced with a similar medication, this should be done little by little over a minimum of 1 week (a long period may be necessary at the discretion of the doctor who prescribes it).
In grown-up patients with posttherpetic neuralgia, treatment with Gabapentin may be started as a single 300-mg dose on Day 1, 600 mg / day on Day 2, and 900 mg / day on Day 3. The dose can be then titrated up as needed for pain alleviation to a daily dose of 1800 mg. In clinical studies, efficiency was shown over a dose range from 1800 mg / day to 3600 mg / day with equivalent effects across the dose range. Extra benefit of taking doses greater than 1800 mg / day was not demonstrated.
Gabapentin is prescriptible for additional therapy in patients at least 3 years of age. Effectiveness in pediatric patients below the age of 3 years has not been ascertained.
Patients 12 years of age
The successful dosage of Gabapentin is 900 to 1800 mg / day and given in divided doses (three times per day) using 300 or 400 mg capsules, or 600 or 800 mg tablets. The initial dose is 300 mg thrice daily. If necessary, the dosage could be augmented using 300 or 400 mg capsules, or 600 or 800 mg tablets three times daily up to 1800 mg / day. Amounts up to 2400 mg / day have been well accepted in long-term clinical studies. Doses of 3600 mg / day have also been given to several patients for a short short duration, and have been well accepted. The longest time between doses in the TID schedule should not exceed 12 hours.
Kids Age 3-12 years
The first dose should be from 10-15 mg / kg / day in 3 divided doses, and the efficient dose attained by upward titration duringapproximately 3 days. The efficient dose of Gabapentin in patients more than 5 years of age is 25-35 mg / kg / day and given in divided doses (thrice a day). The effective dose in children ages 3 and 4 years is 40 mg / kg / day and administered in divided doses ((in three doses.) Neurontin may be prescribed as the oral solution, capsule, or tablet, or using combinations of these formulas. Dosages up to 50 mg / kg / day have been well received in a long-term clinical study.
If Gabapentin is not administrated anymore and / or a similar anticonvulsant is added to the treatment, this should be done gradually over a minimum of 1 week.
Dosage in Renal Impairment
Dosage correction in patients at least 12 years of age with renal dysfunction or undergoing hemodialysis is prescribed following strict dosing indications above for efficient doses in each indication.
Gabapentin employment in patients less than 12 years of age with renal impairment has not been studied.