Diabetes Medication Can Increase Risk For Broken Bones

Unfortunately, to say diabetes is a difficult disease to live with and treat is an understatement. It can adversely affect almost every part of your body. It can damage the eyes, kidneys, cardiovascular system, nervous system, and other parts of the body. However, did you know even some anti-diabetic medications can affect your body?

If you have diabetes, you may want to be very careful about breaking bones. New research has found that diabetes slows bone healing in mice. Recently, the American Journal of Pathology published an article reporting that the increased production of an inflammatory molecule called TNF may cause bones to heal more slowly and less satisfactorily. In a study done on mice at the Univeristy of Medicine and Dentistry of New Jersey and Boston School of Medicine, diabetic mice had an increased number of inflammatory molecules, especially, TNF-alpha and a mediater called FOXO1. Apparently, the increase in inflammation molecules caused an increase in osteodasts. Oesteodasts are cells that remove bone and cartilage.

Furthermore, other new research has found that a certain class of anti-diabetic medication called thiazolidinediones (TZDs) also called glitazones may increase the risk of fractures. TZDs are used to treat diabetes II only. The most common TZDs are Actos and Avandia.

At the London School of Hygiene and Tropical Medicines, colleagues searched through the databases of more than 6 million patients in the United Kingdom over the age of 40 and found that 1,819 patients prescribed TZDs had a bone fracture. After adjusting for the fact that older people are more likely to break bones, they found patients prescribed TZDs were 1.5 times more likely to break a bone. The longer the medication was taken, the more the risk increased.

In addition to this new information, over the years, there has been conflicting information about diabetes and bone density.

Consequently, especially if you have diabetes II and take one of these medications, these are very good reasons to try to lower your blood sugar levels.