Cirrhosis of liver


Cirrhosis is a chronic medical condition of liver abandoning the usual biochemical functioning of liver in the body. Cirrhosis is resulted from the surrogation of the liver tissues by regenerative nodules and fibrotic scar nodules that lead to the progressive loss of biochemical function of the liver. The common causes of Cirrhosis are hepatitis C, chronic hepatitis B; Wilson’s disease, autoimmune hepatitis, hereditary hemochromatosis, alcoholism etc. and this become a crucial health problem of the mankind.
The nodule formation and fibrosis lead to the alteration of the ordinary liver structure which obstructs the blood flow throughout the liver is the condition of Cirrhosis. Cirrhosis also leads to an incapability of performing liver biochemical functions. The pathophysiology of cirrhosis, the normal and anatomy of the liver provide the better understanding of the hazards of Cirrhosis. The liver is an important organ in the animal body where also where metabolism of toxins and drugs including alcohol are carried out.

The biochemical functions of liver includes the synthesis of blood clotting factors, secretion and synthesis of albumin, the chief blood protein, secretion of bile and modification of its components. In addition, cholesterol metabolism and the conversion of fats and proteins into glucose like primary biochemical functions are also performed by the liver. Thus liver plays an important role in the functioning of the human body and deterioration in its functioning like by cirrhosis is of major biomedical concern and diagnosing the disease and immediate treatment is the best solution.

Liver biopsy through a transjugular, percutaneous, fine-needle or laparoscopic approach is the best way to diagnose cirrhosis. On the basis of the results obtained from the histological studies cirrhosis can be divided into macronodular, micronodular, or mixed, but it is unfocused to the etiology and these may loss with the progress of the disease and serological sign are greatly specific. If the laboratory, clinical, and radiological records suggests cirrhosis them there is no requirement of going for liver biopsy.

The only treatment of liver cirrhosis is the elimination of the causes and preventing complications of the disease. There is no such treatment to get the liver cirrhosis reversed back to the original healthy liver. Abstaining from alcoholism, timely treatment of hepatitis associated cirrhosis and other cirrhosis causing diseases are the ways for eliminating cirrhosis. If the cause is Wilson’s disease then chelation therapy for removing the copper that build up in the body by this disease is effective.

Medications including antibiotics are the best ways of preventing the complications of cirrhosis due to different causes. If the complications outbreaks the limit of control then liver transplantation is preferable. With advancement in the biomedical sciences the chances of survival on liver transplantation or the success of it inflating and thus giving new hope of curing to the cirrhosis sufferers.