Antifungal Drugs And Their Actions In Specific Diseases

Antifugal drugs simply means drugs fighting against fungal infections. Several drugs are now available for specific therapy of mycotic (fungal) infections. Here is a short list of drugs that are currently available.

Amphoterecin B
Dose: 0.5 mg / Kg / day intravenous infusion daily or 0.8-1 mg / Kg / intravenous infusion in 5% glucose over 4-6 hours. Main toxicity: Phlebitis, vomiting, nephrotoxicity, anaphylaxis, hypomagnesemia, hypokalemia.

Flucytosine
Dose: 37.5 mg / Kg / orally 6 hours for 6 weeks. Its sides effects are: Nausea, vomiting, leucopenia, thrombocytopenia, hepatic dysfunction.

Griseofulvin
Dose: 500-1000 mg oral for 2 weeks-1 year. Its main toxicity are: photosensitivity, urticaria, gastrointestinal disturbance and hepatotoxicity.

2-Hydroxystilbamidine
Dose: 225-250 mg in 5% glucose drip over 2-3 hours / daily. Total is 7-8g in a course. Side effects are: Hypotension, allergy, hepatotoxicity.

Ketoconazole
Dose: 200-400 mg Orally daily. Main toxicity are: rashes, hepatotoxicity, gynecomastia.

Miconazole
Dose: oral gel, 125 mg. qid; parenteral 500-1000 mg intravenous 8 hours; intrathecal 20 mg; topical 2% cream or 100 mg pessary. Main toxicity are: Mild local reaction, anaphylaxis, nephrotoxicity, hyponatremia, hyperlipidemia and acute psychosis.

Nystatin
Dose: Oral-50,000 U 6 hours; topical 10,000 U / g ointment or vaginal tablet. Complications are: Rash, lymphadenopathy, parotitis, lacrimation, dermatitis.

Clotrimazole
Dose: 1% cream or 100 mg. Vaginal tablet for 6 days. Mild local effects is a possible toxicity.

Econazole
Dose: 1% cream or powder. Complications are yet to be known

Potassium Iodide
Dose: saturated 1 g / ml. 10 drops qid oral increased to 40 drops 8 hours oral, if tolerated.

There are lots more antifungal drugs and in fact more researchers on ground in discovering others but these are the basic and most common ones in use in today's medicine.